BCRX

BioCryst Pharmaceuticals Inc

BCRX.US biocryst.com + Research + Basket
CIK 0000882796
Employees 435
Phone 919 859 1302
Fiscal year end December
IPO Mar 03, 1994
Address 4505 Emperor Boulevard, Durham, NC, United States, 27703
8.24
-0.33 (-3.85%)
USD · NASDAQ
52-week range
6.23
11.22
Trading at 40% of the 52-week range
Market Cap
2.19B
P/E Ratio
0.00
Forward P/E
14.35
Book Value
-1.78
Div. Yield
N/A
% Institutions
105.91%
% Insiders
1.28%

1 Year

+21.9%

3 Year

+39.0%

10 Year

+83.5%
Description

BioCryst Pharmaceuticals, Inc., a biotechnology company, developing and commercializing medicines for hereditary angioedema (HAE) and other rare diseases. The company markets peramivir injection, an intravenous neuraminidase inhibitor for the treatment of acute uncomplicated and seasonal influenza under the RAPIVAB, RAPIACTA, and PERAMIFLU names; and ORLADEYO, an oral serine protease inhibitor to treat HAE. It is also developing BCX17725, a protein therapeutic for netherton syndrome which is in phase 1; Avoralstat, an ocular plasma kallikrein inhibitor for diabetic macular edema that is in Phase 1; Navenibart, a monoclonal antibody plasma kallikrein inhibitor for HAE which is in Phase 3; BCX17725, an investigational protein therapeutic KLK5 inhibitor for the treatment of netherton syndrome that is in phase 1 clinical trial; STAR-0310, a monoclonal antibody OX40 antagonist for the treatment of atopic dermatitis which is in Phase 1a trial. The company has collaborations and in-license relationships with the Torii Pharmaceutical Co., Ltd., Shionogi & Co., Ltd., and Green Cross Corporation; National Institute of Allergy and Infectious Diseases; Biomedical Advanced Research and Development Authority; the U.S. Department of Health and Human Services; and Albert Einstein College of Medicine of Yeshiva University and Industrial Research, Ltd. BioCryst Pharmaceuticals, Inc. was founded in 1986 and is headquartered in Durham, North Carolina.

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People

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Directors & Officers

Name Title Year Born
Mr. Charles K. Gayer CEO, President & Director 1971
Mr. Babar Ghias CFO & Head of Corporate Development 1979
Ms. Alane P. Barnes Senior VP, Chief Legal Officer & Corporate Secretary 1966
Mr. John Ruesch Chief Technical Operations Officer NA
Dr. David W. Jenkins M.A., Ph.D. Chief Scientific Officer NA
Nick Wilder Manager of Investor Relations NA
Ms. Stephanie Angelini Chief People Officer & Communications Officer NA
Dr. William P. Sheridan MBBS Chief Development Officer 1955
Dr. Yarlagadda S. Babu Ph.D. Chief Discovery Officer 1953
Ms. Jinky Ang Rosselli Chief Data Innovation Officer NA

Insider Trading

Open insider trading
Date Insider Name Title Transaction Type Shares Price Value SEC
Mar 16, 2026 Alane P Barnes N/A Sale 150.00K $9.15 $1.37M SEC
Dec 22, 2025 Alane P Barnes N/A Sale 21.77K $7.65 $166.56K SEC
Dec 03, 2025 Alane P Barnes N/A Sale 19.77K $7.65 $151.24K SEC
Dec 02, 2025 Alane P Barnes N/A Sale 50.91K $7.21 $367.03K SEC
Dec 01, 2025 Alane P Barnes N/A Sale 91.00K $7.10 $646.13K SEC
Nov 13, 2025 Gilbert Ray Cisneros, Jr. N/A Purchase N/A $6.90 N/A —
Aug 13, 2025 Theresa Heggie N/A Sale 70.00K $8.51 $595.70K SEC

Shareholders

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Institutional Holders

Holder Name Shares Date Reported % Out Value % Change
BlackRock Inc 23.89M Jun 30, 2026 9.35% $0.00 5.48%
RA Capital Management, LLC 15.83M Jun 30, 2026 6.19% $1.38 0.00%
State Street Corp 15.19M Jun 30, 2026 5.94% $0.00 24.43%
Deerfield Management Co 15.10M Jun 30, 2026 5.91% $1.57 0.39%
Vanguard Capital Management, LLC 11.36M Jun 30, 2026 4.45% $0.00 2.05%
Vanguard Portfolio Management, LLC 11.14M Jun 30, 2026 4.36% $0.01 -0.94%
TCG Crossover Management, LLC 11.02M Jun 30, 2026 4.31% $2.65 0.00%
Perceptive Advisors LLC 10.31M Jun 30, 2026 4.03% $1.55 38.67%
Jupiter Topco LLC 9.54M Jun 30, 2026 3.73% $0.04 0.00%
Vestal Point Capital LP 8.30M Jun 30, 2026 3.25% $1.94 18.15%
Two Sigma Investments LLC 6.78M Jun 30, 2026 2.65% $0.05 5.99%
Geode Capital Management, LLC 6.25M Jun 30, 2026 2.45% $0.00 8.05%
Aberdeen Group PLC 5.31M Jun 30, 2026 2.08% $0.07 5.36%
UBS Group AG 5.08M Jun 30, 2026 1.99% $0.01 2.72%
Bank of America Corp 4.80M Jun 30, 2026 1.88% $0.00 -5.70%
The Goldman Sachs Group Inc 4.48M Jun 30, 2026 1.75% $0.00 90.93%
Frazier Life Sciences Management, L.P. 4.01M Jun 30, 2026 1.57% $0.87 0.00%
Nuveen, LLC 4.01M Jun 30, 2026 1.57% $0.01 4.92%
Nantahala Capital Management, LLC 3.80M Jun 30, 2026 1.49% $0.63 91.32%
Millennium Management LLC 3.39M Jun 30, 2026 1.33% $0.01 1,708.39%

Fund Holdings

Rank Holder Name Shares Held % of Shares Change Date Reported
1 Vanguard MStar Total Stk Mkt Idx Invest 8.12M 3.18% ▲ 0.40% Sep 30, 2026
2 State Street® SPDR® S&P® Biotech ETF 7.20M 2.82% ▼ 0.80% Oct 29, 2026
3 iShares Russell 2000 ETF 5.63M 2.21% ▼ 0.41% Oct 29, 2026
4 Vanguard Small Cap Index 2.88M 1.13% ▼ 1.51% Sep 30, 2026
5 abrdn Healthcare Investors 2.62M 1.03% ▲ 0.00% Sep 30, 2026
6 Fidelity Small Cap Index 2.54M 0.99% ▲ 0.88% Jul 31, 2026
7 abrdn Healthcare Opportunities 2.32M 0.91% ▲ 0.00% Sep 30, 2026
8 Candriam Eqs L Biotech C USD Cap 2.22M 0.87% ▼ 2.88% Apr 30, 2026
9 iShares Russell 2000 Growth ETF 2.11M 0.83% ▲ 0.25% Oct 29, 2026
10 Janus Henderson Hrzn Biotec E2 USD 2.09M 0.82% ▲ 12.59% Jun 30, 2026

Financial Highlights

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Market Cap: $2.19B
EBITDA: $433.05M
PEG Ratio: $9.39
Book Value: $-1.78
Earnings/Share: $-1.40
Profit Margin: -40.90%
Operating Margin: 45.12%
ROA (TTM): 52.86%
ROE (TTM): -1,925.37%
Revenue (TTM): $940.61M
Revenue/Share (TTM): $4.10
Earnings Growth (YOY): 1,400.00%
Revenue Growth (YOY): 33.60%

Valuation Metrics

Enterprise Value: $2.55B
Trailing P/E: 0.00
Forward P/E: 14.35

Shares Statistics

Shares Outstanding: 255.54M
Shares Float: 222.32M
% Insiders: 1.28%
% Institutions: 105.91%
Shares Short: 26.60M
Shares Short (Prior Month): 27.49M
Short Ratio: 4.97
Short % Float: 10.49%

Stock Price History

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1 Year Price History

3 Years Price History

10 Years Price History

Max Price History

Financial Charts

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Open balance sheet Open capital intensity Download Financials (Excel)

Revenue, Net Income & Operating Cash Flow (Yearly)

Change % vs Prior Year

Revenue, Net Income & Operating Cash Flow (Quarterly)

Change % vs Prior Quarter

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

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Open full waterfall Open balance sheet
Line Item
Step Type
Value
Revenue
adjust
$874.84M
Cost of Goods Sold
adjust
$-19.08M
Gross Profit
subtotal
$855.76M
SG&A
adjust
$-348.65M
R&D
adjust
$-166.13M
Operating Income
subtotal
$340.99M
Other / Non-Operating Items
adjust
$-77.13M
Net Income
subtotal
$263.86M

Earnings Per Share (EPS) History

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Financial Ratios

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📦 Raw API Data (JSON Explorer)

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