KPTI
Karyopharm Therapeutics Inc

KPTI.US karyopharm.com
Healthcare · Biotechnology
1.62
-0.07 (-4.14%)
USD · NASDAQ
52-week range
1.60
10.99
Trading at 0% of the 52-week range
Market Cap
36.74M
P/E Ratio
0.00
Forward P/E
0.00
Book Value
-14.56
Div. Yield
N/A
% Institutions
97.98%
% Insiders
4.67%
1 Year

-73.9%
3 Year

-91.1%
10 Year

-98.8%
Description
Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compounds include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma; in combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma; and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). It also develops Selinexor for treating hematological and solid tumor malignancies, including multiple myeloma, endometrial cancer, myelofibrosis, and DLBCL; and ELTANEXOR for treating other myeloproliferative neoplasms and TP53 wild-type solid tumors. In addition, the company has license agreement with Menarini Group to develop and commercialize selinexor for human oncology indications; license agreement with Antengene Therapeutics Limited to develop and commercialize selinexor, eltanexor, and KPT-9274 for the treatment and/or prevention of human oncology indications, as well as verdinexor for the diagnosis, treatment, and/or prevention of human non-oncology indications; and distribution agreement for the commercialization of XPOVIO with FORUS Therapeutics Inc. Further, the company has a collaboration with Bristol Myers Squibb company to evaluate novel cereblon E3 ligase modulator agent mezigdomide in combination with Selinexor in patients with relapsed or refractory multiple myeloma. Karyopharm Therapeutics Inc. was incorporated in 2008 and is headquartered in Newton, Massachusetts.
People

▼
Directors & Officers

Name	Title	Year Born
Mr. Richard A. Paulson M.B.A.	President, CEO & Director	1967
Mr. Stuart Poulton	Executive VP & Chief Development Officer	1973
Dr. Reshma Rangwala M.D., Ph.D.	Executive VP, Chief Medical Officer & Head of Research	1978
Dr. Sharon Shacham M.B.A., Ph.D.	Co-Founder & Chairman of Scientific Advisory Board	1970
Ms. Lori A. Macomber CPA	EVP, CFO & Treasurer	1971
Ms. Kristin Abate	VP, Chief Accounting Officer & Assistant Treasurer	NA
Mr. Brendan Twohig Strong	Senior Vice President of Investor Relations	NA
Mr. Michael J. Mano J.D.	Executive VP, Chief Legal Officer & Secretary	1977
Mr. James Accumanno J.D.	Chief Compliance Officer	NA
Ms. Lisa DiPaolo	Executive VP & Chief Human Resource Officer	NA
Insider Trading

Date	Insider Name	Title	Transaction Type	Shares	Price	Value
Apr 21, 2026	Reshma Rangwala	N/A	Sale	449.00	$8.94	$4.01K
Jan 28, 2026	Kristin Abate	N/A	Sale	50.00	$7.03	$351.50
Jan 21, 2026	Kristin Abate	N/A	Sale	265.00	$5.96	$1.58K
Oct 01, 2025	Kristin Abate	N/A	Sale	362.00	$6.30	$2.28K
Sep 15, 2025	Kristin Abate	N/A	Sale	23.00	$6.43	$147.89
Sep 15, 2025	Michael Mano	N/A	Sale	234.00	$6.43	$1.50K
Sep 15, 2025	Reshma Rangwala	N/A	Sale	408.00	$6.43	$2.62K
Sep 15, 2025	Sohanya Roshan Cheng	N/A	Sale	325.00	$6.43	$2.09K
Sep 15, 2025	Stuart Poulton	N/A	Sale	401.00	$6.43	$2.58K
Sep 03, 2025	Kristin Abate	N/A	Sale	12.00	$6.78	$81.36
Jul 29, 2025	Stuart Poulton	N/A	Sale	191.00	$4.37	$834.67
Jul 22, 2025	Kristin Abate	N/A	Sale	238.00	$4.00	$952.00
Shareholders

▼
Institutional Holders

Holder Name	Shares	Date Reported	% Out	Value	% Change
COMMODORE CAPITAL LP	1.95M	Mar 31, 2026	8.60%	$0.63	0.00%
RA Capital Management, LLC	1.92M	Mar 31, 2026	8.45%	$0.11	0.00%
T. Rowe Price Investment Management,Inc.	1.54M	Mar 31, 2026	6.80%	$0.01	-25.77%
Adage Capital Partners Gp LLC	1.52M	Jun 30, 2026	6.71%	$0.02	-15.78%
The Goldman Sachs Group Inc	947.58K	Mar 31, 2026	4.18%	$0.00	0.00%
Catalio Capital Management, LP	940.86K	Jun 30, 2026	4.15%	$1.73	4.81%
Avidity Partners Management LP	924.49K	Jun 30, 2026	4.08%	$1.45	-0.32%
Vanguard Capital Management, LLC	739.75K	Mar 31, 2026	3.26%	$0.00	0.00%
Ikarian Capital, LLC	733.44K	Mar 31, 2026	3.23%	$0.33	34.69%
Affinity Asset Advisors, LLC	500.00K	Mar 31, 2026	2.20%	$0.14	-43.79%
Soleus Capital Management, L.P.	440.00K	Jun 30, 2026	1.94%	$0.15	0.00%
Millennium Management LLC	305.68K	Jun 30, 2026	1.35%	$0.00	-27.32%
Boxer Capital Management, LLC	302.54K	Mar 31, 2026	1.33%	$0.22	19.80%
Davidson Kempner Capital Management LP	300.00K	Mar 31, 2026	1.32%	$0.02	-3.23%
Eversept Partners, LP	276.17K	Jun 30, 2026	1.22%	$0.14	0.00%
Jump Financial LLC	262.15K	Mar 31, 2026	1.16%	$0.02	387.12%
Trexquant Investment LP	257.90K	Mar 31, 2026	1.14%	$0.01	517.98%
Acadian Asset Management LLC	248.96K	Mar 31, 2026	1.10%	$0.00	0.00%
BlackRock Inc	244.90K	Mar 31, 2026	1.08%	$0.00	-1.07%
BOOTHBAY FUND MANAGEMENT, LLC	213.81K	Mar 31, 2026	0.94%	$0.02	47.83%
Fund Holdings

Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	Vanguard MStar Total Stk Mkt Idx Invest	677.73K	2.99%	▲ 0.00%	Jul 31, 2026
2	iShares Russell 2000 ETF	482.93K	2.13%	▼ 0.57%	Aug 31, 2026
3	T. Rowe Price U.S. SC Value Eq Tr-D	312.41K	1.38%	▼ 48.87%	Jun 30, 2026
4	Vanguard Institutional Extnd Mkt Idx Tr	263.08K	1.16%	▲ 0.00%	Jul 31, 2026
5	Fidelity Small Cap Index	214.60K	0.95%	▲ 0.00%	Jun 30, 2026
6	Fidelity Enhanced Small Cap Core ETF	174.36K	0.77%	▲ 0.29%	Aug 31, 2026
7	iShares Russell 2000 Value ETF	151.90K	0.67%	▼ 0.23%	Aug 31, 2026
8	Russell 2000 Index Non-Lendable Fund	128.78K	0.57%	▲ 0.00%	Jun 30, 2026
9	Russell 2000 Equity Index Fund B	128.78K	0.57%	▲ 0.00%	Jun 30, 2026
10	Vanguard Russell 2000 ETF	111.50K	0.49%	▼ 3.17%	Jul 31, 2026
Financial Highlights

▼
Market Cap: $36.74M
EBITDA: $-82.20M
PEG Ratio: $-0.15
Book Value: $-14.56
Earnings/Share: $-13.74
Profit Margin: -153.28%
Operating Margin: -67.38%
ROA (TTM): -47.61%
ROE (TTM): -891.05%
Revenue (TTM): $146.62M
Revenue/Share (TTM): $7.55
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): -11.90%
Valuation Metrics

Enterprise Value: $229.42M
Trailing P/E: 0.00
Forward P/E: 0.00
Shares Statistics

Shares Outstanding: 22.68M
Shares Float: 15.77M
% Insiders: 4.67%
% Institutions: 97.98%
Short % Float: 42.72%
Stock Price History

▼
1 Year Price History

3 Years Price History

10 Years Price History

Financial Charts

▼
Download Financials (Excel)
Revenue, Net Income & Operating Cash Flow (Yearly)

Revenue, Net Income & Operating Cash Flow (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

▼
Line Item
Step Type
Value
Revenue
adjust
$146.07M
Cost of Goods Sold
adjust
$-5.95M
Gross Profit
subtotal
$140.12M
SG&A
adjust
$-105.21M
R&D
adjust
$-125.62M
Operating Income
subtotal
$-90.71M
Other / Non-Operating Items
adjust
$-105.33M
Net Income
subtotal
$-196.04M
Earnings Per Share (EPS) History

▼
Financial Ratios

▼
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
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    "General": {
        "Code": "KPTI",
        "Type": "Common Stock",
        "Name": "Karyopharm Therapeutics Inc",
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}
Karyopharm Therapeutics Inc

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