ORKA
Oruka Therapeutics, Inc.

ORKA.US orukatx.com + Research + Basket
Healthcare · Biotechnology
CIK 0000907654
Employees 68
Phone 650 606 7910
Fiscal year end December
IPO Aug 08, 1997
Address 855 Oak Grove Avenue, Menlo Park, CA, United States, 94025
101.41
+1.86 (+1.87%)
USD · NASDAQ
52-week range
25.23
115.52
Trading at 84% of the 52-week range
Market Cap
6.59B
P/E Ratio
0.00
Forward P/E
0.00
Book Value
18.20
Div. Yield
N/A
% Institutions
117.14%
% Insiders
1.26%
1 Year

+269.7%
3 Year

+754.0%
10 Year

-61.2%
Description
Oruka Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing novel monoclonal antibody therapeutics for psoriasis (PsO), and other inflammatory and immunology (I&I) indications. Its lead products include ORKA-001 that targets p19 subunit of interleukin-23, which is in phase 2a trial for the treatment of PsO; and ORKA-002 that targets interleukin-17A and interleukin-17F, which is in phase 2 trial for the treatment of PsO, psoriatic arthritis, and other conditions. The company also develops ORKA-003 for targeting an undisclosed pathway; and ORKA-021, a sequential combination regimen of ORKA-002 and ORKA-001. Oruka Therapeutics, Inc. is headquartered in Menlo Park, California.
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People

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Directors & Officers

Name	Title	Year Born
Dr. Lawrence Otto Klein Ph.D.	President, CEO & Director	1983
Mr. Paul T. Quinlan	General Counsel & Secretary	1963
Dr. Joana Goncalves M.D.	Chief Medical Officer	1974
Mr. Arjun Agarwal CPA	Senior VP of Finance & Treasurer	1976
Ms. Laura Sandler	Chief Operating Officer	1977
Mr. Alan Lada	VP of IR & Capital Markets	NA
Mr. Christopher Finch	Senior VP and Head of Business Development & Strategy	NA
Dr. Rajiv Panwar	Senior VP and Head of Chemistry, Manufacturing & Controls	NA
Mr. Larry Todd Edwards	Chief Commercial Officer	1963
Insider Trading

Open insider trading
Date	Insider Name	Title	Transaction Type	Shares	Price	Value	SEC
Apr 15, 2026	Joana Goncalves	N/A	Sale	7.00K	$66.12	$462.84K	SEC
Mar 16, 2026	Arjun Agarwal	N/A	Sale	395.00	$41.30	$16.31K	SEC
Mar 16, 2026	Joana Goncalves	N/A	Sale	7.64K	$40.91	$312.59K	SEC
Mar 16, 2026	Lawrence Otto Klein	N/A	Sale	1.73K	$41.30	$71.41K	SEC
Feb 17, 2026	Joana Goncalves	N/A	Sale	7.00K	$32.37	$226.59K	SEC
Jan 15, 2026	Joana Goncalves	N/A	Sale	7.00K	$31.81	$222.67K	SEC
Dec 19, 2025	Joana Goncalves	N/A	Sale	7.00K	$30.61	$214.27K	SEC
Shareholders

▼
Institutional Holders

Holder Name	Shares	Date Reported	% Out	Value	% Change
FMR Inc	9.06M	Jun 30, 2026	13.68%	$0.04	21.88%
BlackRock Inc	4.99M	Jun 30, 2026	7.54%	$0.01	41.48%
VR Adviser, LLC	4.15M	Jun 30, 2026	6.27%	$11.97	0.00%
Fairmount Funds Management LLC	3.71M	Jun 30, 2026	5.60%	$23.31	0.00%
Capital World Investors	3.40M	Jun 30, 2026	5.14%	$0.04	0.00%
RTW INVESTMENTS, LLC	3.14M	Jun 30, 2026	4.74%	$2.55	52.52%
State Street Corp	2.67M	Jun 30, 2026	4.04%	$0.01	65.67%
Vanguard Capital Management, LLC	2.36M	Jun 30, 2026	3.57%	$0.00	26.96%
Paradigm Biocapital Advisors LP	2.14M	Jun 30, 2026	3.24%	$3.82	-7.58%
Deep Track Capital, LP	1.93M	Jun 30, 2026	2.91%	$2.67	-5.32%
Bellevue Group AG	1.66M	Jun 30, 2026	2.50%	$3.32	226.86%
Franklin Templeton Inc	1.62M	Jun 30, 2026	2.45%	$0.03	61.49%
Remedium Capital Partners, LLC	1.57M	Jun 30, 2026	2.36%	$32.99	0.00%
RA Capital Management, LLC	1.55M	Jun 30, 2026	2.35%	$1.29	0.00%
Viking Global Investors LP	1.50M	Jun 30, 2026	2.27%	$0.41	-43.62%
Geode Capital Management, LLC	1.43M	Jun 30, 2026	2.16%	$0.01	49.75%
Jupiter Topco LLC	1.38M	Jun 30, 2026	2.08%	$0.05	0.00%
Perceptive Advisors LLC	1.35M	Jun 30, 2026	2.03%	$1.92	-3.61%
Polar Capital Holdings PLC	1.23M	Jun 30, 2026	1.86%	$0.28	17.27%
Citadel Advisors Llc	1.12M	Jun 30, 2026	1.69%	$0.01	11.06%
Fund Holdings

Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	Vanguard MStar Total Stk Mkt Idx Invest	1.90M	2.87%	▲ 9.95%	Sep 30, 2026
2	State Street® SPDR® S&P® Biotech ETF	1.69M	2.55%	▼ 0.80%	Oct 29, 2026
3	American Funds SMALLCAP World A	1.53M	2.31%	▲ 0.00%	Sep 30, 2026
4	American Funds New Economy A	1.32M	2.00%	▲ 0.00%	Sep 30, 2026
5	Fidelity Growth Company Fund	1.29M	1.95%	▲ 0.00%	Aug 31, 2026
6	iShares Russell 2000 ETF	1.28M	1.93%	▼ 0.41%	Oct 29, 2026
7	Polar Capital Biotech S Inc	1.16M	1.76%	▲ 0.00%	Sep 30, 2026
8	Fidelity Select Health Care	880.00K	1.33%	▲ 1.73%	Aug 31, 2026
9	Fidelity Advisor Biotechnology I	737.39K	1.11%	▲ 0.00%	Aug 31, 2026
10	Fidelity Small Cap Growth	685.72K	1.04%	▲ 0.00%	Jul 31, 2026
Financial Highlights

▼
Market Cap: $6.59B
EBITDA: $-154.94M
Book Value: $18.20
Earnings/Share: $-2.13
Profit Margin: 0.00%
Operating Margin: 0.00%
ROA (TTM): -12.95%
ROE (TTM): -18.23%
Revenue (TTM): $0.00
Revenue/Share (TTM): $0.00
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): 0.00%
Valuation Metrics

Enterprise Value: $5.45B
Trailing P/E: 0.00
Forward P/E: 0.00
Shares Statistics

Shares Outstanding: 66.21M
Shares Float: 56.89M
% Insiders: 1.26%
% Institutions: 117.14%
Shares Short: 6.11M
Shares Short (Prior Month): 7.78M
Short Ratio: 5.86
Short % Float: 13.44%
Stock Price History

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1 Year Price History

3 Years Price History

10 Years Price History

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Financial Charts

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Open balance sheet Open capital intensity Download Financials (Excel)
Revenue, Net Income & Operating Cash Flow (Yearly)

Change % vs Prior Year

Revenue, Net Income & Operating Cash Flow (Quarterly)

Change % vs Prior Quarter

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

▼
Line Item
Step Type
Value
Revenue
adjust
$0.00
Cost of Goods Sold
adjust
$-83.00K
Gross Profit
subtotal
$-83.00K
SG&A
adjust
$-21.41M
R&D
adjust
$-100.64M
Operating Income
subtotal
$-122.05M
Other / Non-Operating Items
adjust
$16.62M
Net Income
subtotal
$-105.43M
Earnings Per Share (EPS) History

▼
Financial Ratios

▼
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
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}
Oruka Therapeutics, Inc.

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