SAGE
Sage Therapeutics Inc

SAGE.US sagerx.com + Research + Basket
Healthcare · Biotechnology
CIK 0001597553
Employees 353
Phone 617 299 8380
Fiscal year end December
IPO Jul 18, 2014
Address 55 Cambridge Parkway, Cambridge, MA, United States, 02142
Price N/A
USD · NASDAQ
52-week range
0.00
Market Cap
544.94M
P/E Ratio
0.00
Forward P/E
0.00
Book Value
5.89
Div. Yield
N/A
% Institutions
83.60%
% Insiders
10.36%
1 Year

-20.7%
3 Year

-74.8%
10 Year

-87.2%
Description
Sage Therapeutics, Inc., a biopharmaceutical company, develops and commercializes brain health medicines. The company offers ZURZUVAE, a neuroactive steroid positive allosteric modulator of GABA receptors targeting synaptic and extrasynaptic GABA receptors for the treatment of postpartum depression in adults. Its product pipeline also includes SAGE-324, a novel GABA receptor positive allosteric modulator for chronic oral dosing, including seizures in developmental and epileptic encephalopathies; and SAGE-319, an extrasynaptic-preferring GABA receptor positive allosteric modulator PAM for treating behavioral symptoms associated with neurodevelopmental disorders. In addition, the company is developing various product candidates, including SAGE-817 and SAGE-039 for the treatment of acute and chronic brain health disorders, including work on allosteric modulation of the GABA and NMDA receptor systems in the brain, as well as NMDA receptor negative allosteric modulator focusing on the treatments for neurodevelopmental disorders. The company was formerly known as Sterogen Biopharma, Inc. and changed its name to Sage Therapeutics, Inc. in September 2011. Sage Therapeutics, Inc. was incorporated in 2010 and is headquartered in Cambridge, Massachusetts. As of July 31, 2025, Sage Therapeutics, Inc. operates as a subsidiary of Saphire, Inc.
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People

▼
Directors & Officers

Name	Title	Year Born
Mr. Barry E. Greene	President, CEO & Director	1963
Mr. Christopher Benecchi	COO & Treasurer	1972
Mr. Gregory Shiferman	Senior VP, General Counsel & Secretary	NA
Mr. Michael Quirk Ph.D.	Chief Scientific Officer & Interim Head of R&D	NA
Ms. Ashley Kaplowitz	Director of Investor Relations	NA
Ms. Pamela Herbster	Senior VP and Chief People & Experience Officer	NA
Dr. Helen Colquhoun	Senior Vice President of Drug Safety & Pharmacovigilance	NA
Dr. Aaron Koenig M.D.	Medical Director of Early Clinical Development	NA
Helen Rubinstein	Investor Relations Officer	NA
Insider Trading

Open insider trading
Date	Insider Name	Title	Transaction Type	Shares	Price	Value	SEC
Aug 09, 2023	Elizabeth Barrett	N/A	Purchase	2.00K	$18.64	$37.28K	SEC
May 09, 2023	Elizabeth Barrett	N/A	Purchase	1.00K	$50.50	$50.50K	SEC
Feb 10, 2023	Jeffrey M Jonas	N/A	Sale	11.64K	$44.61	$519.39K	SEC
Shareholders

▼
Institutional Holders

Holder Name	Shares	Date Reported	% Out	Value	% Change
Madison Avenue Partners, LP	6.08M	Jun 30, 2025	9.68%	$3.70	35.72%
BlackRock Inc	4.66M	Mar 31, 2025	7.42%	$0.00	-3.91%
Vanguard Group Inc	3.27M	Jun 30, 2025	5.20%	$0.00	-35.68%
D. E. Shaw & Co LP	1.92M	Jun 30, 2025	3.05%	$0.01	-8.15%
Morgan Stanley - Brokerage Accounts	1.40M	Mar 31, 2025	2.23%	$0.00	-69.55%
BOOTHBAY FUND MANAGEMENT, LLC	1.38M	Mar 31, 2025	2.21%	$0.29	-0.29%
Geode Capital Management, LLC	1.30M	Mar 31, 2025	2.08%	$0.00	3.70%
Eckert Corp	1.27M	Jun 30, 2025	2.03%	$0.62	0.00%
State Street Corp	1.19M	Mar 31, 2025	1.89%	$0.00	-6.61%
683 Capital Management LLC	1.15M	Jun 30, 2025	1.83%	$0.69	15.00%
Marshall Wace Asset Management Ltd	1.15M	Jun 30, 2025	1.83%	$0.01	-34.86%
The Toronto-Dominion Bank	1.08M	Jun 30, 2025	1.72%	$0.02	0.00%
Qube Research & Technologies	1.08M	Jun 30, 2025	1.72%	$0.01	0.00%
Citadel Advisors Llc	1.05M	Mar 31, 2025	1.67%	$0.00	1,144.28%
Harvest Management LLC	889.20K	Jun 30, 2025	1.42%	$3.45	22.45%
Dimensional Fund Advisors, Inc.	874.17K	Jun 30, 2025	1.39%	$0.00	81.45%
AQR Capital Management LLC	861.37K	Jun 30, 2025	1.37%	$0.01	-24.86%
Renaissance Technologies Corp	769.70K	Mar 31, 2025	1.23%	$0.01	70.74%
ADAR1 Capital Management LLC	742.50K	Mar 31, 2025	1.18%	$1.10	3,767.16%
Newtyn Management LLC	700.00K	Jun 30, 2025	1.12%	$0.97	0.00%
Fund Holdings

Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	BB Biotech AG Ord	4.46M	7.11%	▲ 0.00%	Dec 31, 2024
2	Fidelity Small Cap Index	568.57K	0.91%	▲ 3.42%	Jun 30, 2025
3	Nuveen Quant Small Cap Equity R6	427.73K	0.68%	▼ 1.96%	Jun 30, 2025
4	Fidelity Extended Market Index	294.36K	0.47%	▼ 0.26%	Jun 30, 2025
5	Schwab US Small-Cap ETF™	256.13K	0.41%	▲ 0.00%	Jul 31, 2025
6	Federated Hermes MDT SCC Institutional	209.67K	0.33%	▼ 74.48%	Jun 30, 2025
7	Federated Hermes MDT Small Cap Core IS	209.67K	0.33%	▼ 74.48%	Jun 30, 2025
8	Vanguard Growth & Income Inv	206.42K	0.33%	▲ 7.40%	Jun 30, 2025
9	Prisma Global	190.00K	0.30%	▼ 19.83%	Mar 31, 2025
10	Lazard US Sm Cap Eq WW Dist EUR	173.50K	0.28%	▲ 0.00%	May 31, 2025
Financial Highlights

▼
Market Cap: $544.94M
EBITDA: $-302.08M
PEG Ratio: $0.74
Book Value: $5.89
Earnings/Share: $-4.89
Profit Margin: 0.00%
Operating Margin: -171.19%
ROA (TTM): -33.78%
ROE (TTM): -60.43%
Revenue (TTM): $70.41M
Revenue/Share (TTM): $1.14
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): 265.80%
Valuation Metrics

Enterprise Value: $190.79M
Trailing P/E: 0.00
Forward P/E: 0.00
Shares Statistics

Shares Outstanding: 62.78M
Shares Float: 51.31M
% Insiders: 10.36%
% Institutions: 83.60%
Shares Short: 2.22M
Shares Short (Prior Month): 2.81M
Short Ratio: 0.65
Short % Float: 3.94%
Stock Price History

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Financial Charts

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Revenue, Net Income & Operating Cash Flow (Yearly)

Change % vs Prior Year

Revenue, Net Income & Operating Cash Flow (Quarterly)

Change % vs Prior Quarter

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

▼
Line Item
Step Type
Value
Revenue
adjust
$41.24M
Cost of Goods Sold
adjust
$-9.44M
Gross Profit
subtotal
$31.80M
SG&A
adjust
$-216.42M
R&D
adjust
$-225.90M
Other Operating Expense
adjust
$-21.85M
Operating Income
subtotal
$-432.37M
Other / Non-Operating Items
adjust
$31.70M
Net Income
subtotal
$-400.67M
Earnings Per Share (EPS) History

▼
Financial Ratios

▼
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
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}
Sage Therapeutics Inc

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