Stock Fundamentals

Company Information

Company Name
Summit Therapeutics PLC
Sector
Healthcare
Industry
Biotechnology
Exchange
NASDAQ
ISIN: US86627T1088
CIK: 0001599298
CUSIP: 86627R102
Currency: USD
Full Time Employees: 265
Phone: 305 203 2034
Fiscal Year End: December
IPO Date: Mar 05, 2015
Description:

Summit Therapeutics Inc., a biopharmaceutical company, focuses on discovery, development, and commercialization of patient, physician, caregiver, and societal friendly medicinal therapies. Its lead development candidate is ivonescimab, a bispecific antibody for immunotherapy through blockade of PD-1 with the anti-angiogenesis for the treatment of non-small lung cancer (NSCLC) and colorectal cancer (CRC). The company has also combined ivonescimab with chemotherapy, which is in phase III clinical trial for the patients with epidermal growth factor receptor, mutated, and locally advanced or metastatic non-squamous NSCLC; first-line metastatic NSCLC; and first-line unresectable metastatic CRC. It markets its products in the United states, Canada, Europe, Japan, Latin America, Middle East, and Africa. The company was founded in 2003 and is headquartered in Miami, Florida.

Address:

601 Brickell Key Drive, Miami, FL, United States, 33131

Directors & Officers

Name Title Year Born
Mr. Robert W. Duggan Co-CEO & Executive Chairman 1945
Dr. Mahkam Zanganeh D.D.S., M.B.A. Co-CEO, President & Director 1970
Mr. Manmeet Singh Soni CPA COO, CFO & Director 1978
Prof. Kay Elizabeth Davies DBE, FRS CBE Co-Founder, Chairman of Scientific Advisory Board and Scientific Advisor 1951
Mr. Bhaskar Anand Chief Accounting Officer & Head of Finance 1978
Mr. Nathan LiaBraaten Senior Director of Investor Relations NA
Dr. Elaine Carla Stracker J.D., Ph.D. Chief Legal Officer 1961
Mr. Dave Gancarz CPA Chief Business & Strategy Officer NA
Dr. Wang Clow Fong ScD Chief Biometrics Officer 1958
Dr. Urte Gayko Ph.D. Chief Regulatory, Quality & Pharmacovigilance Officer 1971

Insider Trading

Date Insider Name Title Transaction Type Shares Price Value
Oct 21, 2025 Mahkam Zanganeh N/A Purchase 26.68K $18.74 $499.98K
Oct 21, 2025 Robert W Duggan N/A Purchase 26.68K $18.74 $499.98K
Oct 21, 2025 Yu Xia N/A Purchase 533.62K $18.74 $10.00M
Sep 11, 2025 Mahkam Zanganeh N/A Purchase 5.00K $18.07 $90.35K
Sep 11, 2025 Robert W Duggan N/A Purchase 5.00K $18.07 $90.35K
Sep 10, 2025 Mahkam Zanganeh N/A Purchase 333.39K $17.68 $5.89M
Sep 10, 2025 Robert W Duggan N/A Purchase 333.39K $17.68 $5.89M

Institutional Holders

Holder Name Shares Date Reported % Out Value % Change
Baker Bros Advisors LP 36.39M Mar 31, 2026 4.69% $3.96 0.00%
Vanguard Group Inc 11.18M Dec 31, 2025 1.44% $0.00 -1.78%
FMR Inc 10.85M Mar 31, 2026 1.40% $0.01 -18.77%
BlackRock Inc 9.65M Mar 31, 2026 1.24% $0.00 3.12%
T. Rowe Price Associates, Inc. 8.28M Mar 31, 2026 1.07% $0.02 -11.67%
State Street Corp 7.03M Mar 31, 2026 0.91% $0.00 5.90%
Vanguard Capital Management, LLC 5.71M Mar 31, 2026 0.74% $0.00 0.00%
Vanguard Portfolio Management, LLC 5.23M Mar 31, 2026 0.67% $0.01 0.00%
UBS Group AG 3.68M Mar 31, 2026 0.47% $0.01 322.68%
Geode Capital Management, LLC 3.32M Mar 31, 2026 0.43% $0.00 5.35%
D. E. Shaw & Co LP 2.24M Mar 31, 2026 0.29% $0.03 439.93%
Morgan Stanley - Brokerage Accounts 1.65M Mar 31, 2026 0.21% $0.00 78.14%
NORGES BANK 1.37M Dec 31, 2025 0.18% $0.00 -1.15%
Pictet Asset Manangement SA 1.32M Mar 31, 2026 0.17% $0.03 -4.38%
APEIRON CAPITAL Ltd 1.31M Mar 31, 2026 0.17% $23.21 -0.01%
Two Sigma Investments LLC 981.19K Mar 31, 2026 0.13% $0.02 69.68%
Charles Schwab Investment Management Inc 960.87K Mar 31, 2026 0.12% $0.00 7.64%
TD Asset Management Inc 956.89K Mar 31, 2026 0.12% $0.01 -20.61%
Vanguard Fiduciary Trust Co 934.39K Mar 31, 2026 0.12% $0.00 0.00%
SUPERSTRING CAPITAL MANAGEMENT LP 892.87K Mar 31, 2026 0.12% $12.09 0.00%

Shares Statistics

Shares Outstanding: 776.16M
Shares Float: 130.71M
% Insiders: 8,314.00%
% Institutions: 1,585.50%
Short % Float: 29.55%

Fund Holdings

Rank Holder Name Shares Held % of Shares Change Date Reported
1 State Street® SPDR® S&P® Biotech ETF 5.39M 0.69% ▼ 0.61% May 31, 2026
2 Vanguard Total Stock Mkt Idx Inv 3.77M 0.49% ▲ 0.31% Apr 30, 2026
3 Fidelity Growth Compy Commingled Pl S 3.53M 0.45% ▲ 5.03% Apr 30, 2026
4 T. Rowe Price Health Sciences 3.51M 0.45% ▼ 43.17% Apr 30, 2026
5 Vanguard Small Cap Index 2.68M 0.35% ▼ 0.40% Apr 30, 2026
6 Fidelity Growth Company Fund 2.65M 0.34% ▲ 5.23% Apr 30, 2026
7 Vanguard Institutional Extnd Mkt Idx Tr 1.74M 0.22% ▲ 0.79% Apr 30, 2026
8 Vanguard Small Cap Value Index Inv 1.72M 0.22% ▲ 0.71% Apr 30, 2026
9 Fidelity Select Biotechnology 1.07M 0.14% ▼ 1.97% Apr 30, 2026
10 BlackRock Health Sciences Opps Inv A 924.15K 0.12% ▲ 0.00% Apr 30, 2026

Valuation Metrics

Enterprise Value: $11.26B
Trailing P/E: 0.00
Forward P/E: 3.72

Financial Highlights

Market Cap: $11.84B
EBITDA: $-1.22B
PEG Ratio: $0.00
Book Value: $0.70
Earnings/Share: $-1.59
Profit Margin: 0.00%
Operating Margin: 0.00%
ROA (TTM): -148.16%
ROE (TTM): -270.95%
Revenue (TTM): $0.00
Revenue/Share (TTM): $0.00
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): -100.00%

Stock Price History

1 Year Price History

2 Years Price History

5 Years Price History

10 Years Price History

Financial Charts

Revenue & Net Income (Yearly)

Revenue & Net Income (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Earnings Per Share (EPS) History

Financial Ratios

Balance Sheet (Yearly)

Financial Ratios

Date Current Ratio Debt/Equity Debt/Assets Interest Coverage Debt/EBITDA
2025-12-31 9.87x 0.01x 0.12x N/A 0.00x
2024-12-31 10.15x 0.01x 0.11x -20.78x -0.02x
2023-12-31 9.30x 1.66x 0.62x -29.05x -1.47x
2022-12-31 16.93x 4.96x 0.81x -13.55x -9.93x
2021-12-31 3.80x 0.01x 0.27x -306.71x -0.01x
2020-12-31 4.41x 0.00x 0.22x -280.96x -0.01x
2019-12-31 6.27x -0.01x 0.19x 363.01x -0.04x
2018-12-31 3.56x 0.00x 0.30x 8.69x 0.00x
2017-12-31 1.89x 1.29x 0.82x -15.67x -0.68x
2016-12-31 3.06x -1.17x 1.09x -23.08x -0.21x
2015-12-31 6.51x 0.17x 0.16x -57.96x -0.25x
2014-12-31 4.26x 0.00x 0.33x -27.31x 0.00x
2013-12-31 1.66x 0.00x 0.35x -451.92x 0.00x
2012-12-31 2.74x 0.44x 0.35x -2.89x -0.52x
2011-12-31 2.06x 0.32x 0.38x -1,000.86x -0.67x
2010-12-31 3.09x 0.00x 0.28x -1,482.31x 0.00x
2009-12-31 6.01x 0.00x 0.28x -85.97x 0.00x
2008-12-31 2.90x 0.02x 0.39x -164.42x -0.01x
2007-12-31 3.73x 0.01x 0.22x -309.74x -0.02x
2006-12-31 13.53x 0.00x 0.14x -730.31x -0.02x
2005-12-31 18.73x 0.01x 0.10x -273.00x -0.04x
2004-12-31 76.63x 0.00x 0.01x -1.33x -0.22x
2003-12-31 40.01x 0.00x 0.02x -24.00x 0.00x

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